HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Makinodan, T. Articles by Peterson, W. J. Search for Related Content PubMed Articles by Makinodan, T. Articles by Peterson, W. J.

Radiosensitivity of Spleen Cells from Normal and Preimmunized Mice and Its Significance to Intact Animals

Biology Division and the Mathematics Panel, Oak Ridge National Laboratory,¹ Oak Ridge, Tennessee

Abstract

1. The slopes of the regression lines (activity by cell number) were not significantly different (b = 1.014) for primary and secondary antibody responses before and after various sublethal x-ray treatments.

2. The fitted regression [C_m/C_k = 1 - e^-0.0142X)^2.72] of the antibody-forming capacity of spleen cells as a function of x-ray dose was typical of a "multi-target" curve with an extrapolated number of 2.72 and a "D₃₇ value" of 70 r.

3. Exposure of either nonimmunized or pre-immunized donor mice to 150 r caused an 70% decrease in antibody-forming activity of spleen cells and to 250 r, an 90% decrease.

4. No difference in antibody-forming activity was detected between a given number of spleen cells from unirradiated, nonimmunized donors and preimmunized donors given 420 r.

5. The significance of these findings to the role of cellular differentiation (division and maturation) and autoregulatory mechanism in antibody formation and to intact mice are discussed.

Footnotes

¹ Operated by Union Carbide Corporation for the U. S. Atomic Energy Commission.

This article has been cited by other articles:

				J. F. Albright, T. F. Omer, and J. W. Deitchman Antigen Competition: Antigens Compete for a Cell Occurring with Limited Frequency Science, January 9, 1970; 167(3915): 196 - 198. [Abstract] [PDF]

				E. Weiler Immunologically Determined and Competent Cells Are Affected Differentially by Actinomycin D Science, May 15, 1964; 144(3620): 846 - 849. [Abstract] [PDF]