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A Method of Purifying Coxiella Burnetii and Other Pathogenic Rickettsiae

U. S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana

Abstract

A method of readily purifying large amounts of rickettsiae by means of differential, continuous flow centrifugation from molar salt solutions followed by ether treatment has been described.

This technique has been applied to Coxiella burnetii, Rickettsia rickettsii, Rickettsia prowazekii, and Rickettsia mooserii.

Purified preparations of C. burnetii and R. rickettsii prepared in this manner have been shown to possess, when tested as vaccines, protective qualities fully equal to those of conventional rickettsial vaccines.

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