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The Journal of Immunology, 1961, 87: 753-759.
Copyright © 1961 by The American Association of Immunologists, Inc.
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Antigenic Cross-Reactivity between 7 S and 19 S Rabbit {gamma}-Globulin1

G. Jeannette Thorbecke2 and Edward C. Franklin3

Department of Pathology and Medicine, and the Rheumatic Diseases Study Group, New York University School of Medicine, New York City, New York

Abstract

Immunoelectrophoretic analyses of rabbit {gamma}-globulin preparations containing varying amounts of the 19 S fraction have shown that 19 S and 7 S {gamma}-globulin form cross-reacting arcs of different electrophoretic mobility. Pure preparations of 19 S {gamma}-globulin were also shown to cross-react with 7 S {gamma}-globulin in Ouchterlony plates. With an appropriate antiserum both proteins demonstrate spurs, indicating individual as well as common antigenicity.

Absorption of a sheep antiserum to 7 S {gamma}-globulin with fragment III (papain digestion) does not affect the line formed with the 19 S fraction but removes the spur formed by the 7 S fraction.

Absorption of this antiserum with fragments I and II removes the 19 S are but leaves the 7 S line. This demonstrates that 7 S and 19 S rabbit {gamma}-globulin share some of the antigenic groups associated with the antibody carrying fragments of the 7 S molecule.

Footnotes

Supported by U.S.P.H.S. Grants No. E-3076, A-2594 and A-1431.

2 U.S.P.H.S. Senior Research Fellow.

3 Senior Investigator Arthritis and Rheumatism Foundation.




This article has been cited by other articles:


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G. W. Stemke and R. J. Fischer
Rabbit 19S Antibodies with Allotypic Specificities of the a-Locus Group
Science, December 3, 1965; 150(3701): 1298 - 1303.
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J. M Solomon
Equilibration of Isoagglutinins of Human Group O Serum
Science, August 31, 1962; 137(3531): 684 - 685.
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