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Protection of Chick Embryos Against Newcastle Disease Virus by Trypan Blue and Other Compounds

Division of Communicable Disease and Immunology, Walter Reed Army Institute of Research, Washington, District of Columbia

Abstract

Of a number of related compounds tested, Trypan blue, Evans blue, Pontamine sky blue, Trypan red, Congo red and Erie garnet B protect chick embryos against Newcastle disease virus. Although the first four dyes block hemagglutination of NDV, the latter two do not, but they apparently interfere with elution of adsorbed virus. All the active compounds tested are acid, bis-azo dyes with diphenyl and naphthalene residues with two or more sulfonic acid groups. The latter two compounds have the simplest molecular structures.

Trypan blue was also demonstrated to inhibit NDV in cultured mammalian cells. However, it could not be shown to have an effect on influenza virus.