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Some Immunologic Properties of Human and Dog Glomerular Basement Membrane¹

II. Nephritis Produced in Dogs by Rabbit Antihuman Glomerular Basement Membrane Sera

Department of Preventive Medicine, University of Illinois College of Medicine and the Department of Obstetrics and Gynecology, the University of Chicago, Chicago, Illinois

Abstract

1. It has been shown that rabbit anti-HGBM serum and rabbit anti-DGBM serum produce a nephritis in dogs which is indistinguishable using urinary, biochemical or histopathologic criteria. This leads to the conclusion that one or more similar or identical nephrotoxic antigen(s) is present in HGBM and DGBM preparations of the homogeneity herein described.

2. There is likewise one or more similar or identical CF antigen(s) in HGBM and DGBM preparations. The CF and nephrotoxic antigen(s) may not be identical. If not, there are at least two distinct immunologically similar or identical antigens present in HGBM and DGBM.

3. There is urinary and histopathologic evidence of nephritis by at least 20 hr following a single intravenous or intracardiac injection of either antiserum.

4. Biochemically, there is usually evidence of decreased serum albumin and increased serum cholesterol and frequently variable degrees of nitrogen retention. Such changes are similar in both groups of antiserum.

5. The mechanism of the disease is briefly discussed. The fact that an initial mild nephritis may develop into a more marked nephritis in about 6 to 8 days suggests the possibility of a summation of two independent antigen-antibody reactions. An alternative view is that the initial insult produces a variable onset and course, and the lesion slowly becomes progressive itself without requiring a superimposed second antigen-antibody reaction.

Footnotes

This work has been supported (in part) by Research Grant H-4785 from the National Heart Institute of the National Institute of Health, U. S. Public Health Service, and the Schering Corporation.

² Present address: Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois.