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Requirement of Avian C'1 for Fixation of Guinea Pig Complement by Avian Antibody-Antigen Complexes¹

Division of Veterinary Bacteriology and Public Health, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota

Abstract

An incompatibility has been shown to exist between certain avian antibody-antigen complexes and C'1 of guinea pig complement. This can be remedied by the substitution of species specific C'1 after which guinea pig C'2, C'3 and C'4 are fixed.

Footnotes

¹ Scientific Journal series paper No. 4580, Minnesota Agricultural Experiment Station, University of Minnesota, St. Paul. The work on which this paper is based was supported in part by grants from U.S.P.H.S., Animal Disease and Parasite Research Division of the U.S.D.A. It was also taken in part from a thesis submitted by Harold N. Benson in partial fulfillment of the degree of Doctor of Philosophy.