HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Barron, A. L. Articles by Karzon, D. T. Search for Related Content PubMed Articles by Barron, A. L. Articles by Karzon, D. T.

Characteristics of Echo 4 (Shropshire) Virus Isolated during Epidemic of Aseptic Meningitis¹

Department of Bacteriology and Immunology and the Department of Pediatrics, University of Buffalo School of Medicine, Buffalo, New York

Abstract

1. Neutralization tests using hyperimmune monkey antisera or human sera in test tube cultures or by plaque reduction demonstrated antigenic similarity between the Buffalo strains as represented by Shropshire and the prototype ECHO 4 virus.

2. The viruses could be distinguished serologically by the same methods using hyperimmune antisera prepared in rabbits.

3. ECHO 4 antibody response in patients was measured by two methods: a) tube tissue culture neutralization tests employing strain DuToit which was found to be well neutralized by ECHO 4 antibody, and b) plaque reduction tests using either Shropshire or prototype ECHO 4 virus.

Footnotes

¹ This work was aided by grants from The National Foundation, the U. S. Public Health Service (E 2396) and a contract with the Communicable Disease Center, Public Health Service, U. S. Department of Health, Education, and Welfare, Atlanta, Georgia. (Presented in part at the annual meeting of the American Association of Immunologists, Chicago, April, 1960.)

² Markle Scholar in Medical Science.