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Role of the Adrenals in Stress Induced Resistance to Anaphylactic Shock¹

From the Division of Virology, Department of Infectious Diseases, University of California, School of Medicine, Los Angeles, California

Abstract

1. An increase in resistance to passive anaphylaxis in mice regularly follows acute, 6 hr, or chronic, 6 hr per day for 4 weeks, shuttle box stress. This increase in resistance did not develop in stressed, adrenalectomized mice.

2. Treatment of adrenalectomized mice with hydrocortisone acetate resulted in an increase in resistance to anaphylaxis.

3. Acute stress exerted an additive protective effect to that of hydrocortisone in intact but not in adrenalectomized animals.

4. The incidental stress of isolation resulted in a slight but definite increase in resistance to anaphylaxis.

Footnotes

Supported by research grants from the National Institutes of Allergy and Infectious Diseases and of Mental Health, USPHS.

² Postdoctoral Trainee, Mental Health Training Program, USPHS 2 M 6415. Present address: Department of Microbiology, University of Minnesota.

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