HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stollar, D. Articles by Levine, L. Search for Related Content PubMed Articles by Stollar, D. Articles by Levine, L.

Antibodies to Denatured Desoxyribonucleic Acid in a Lupus Erythematosus Serum¹

From the Graduate Department of Biochemistry, Brandeis University, ³ Waltham, Massachusetts

Abstract

The reaction between the serum of a patient with disseminated lupus erythematosus and DNA has been studied by quantitative complement fixation. Thermally denatured DNA was shown to be a more reactive antigen than native DNA. Immunologic measurement of melting out and renaturation of the antigen characterized it as DNA. DNase-digested antigen preparations failed to react but were effective inhibitors. Lupus erythematosus (LE) serum detected serologic differences in denatured DNA preparations from various sources.

Footnotes

Supported in part by grants from the American Cancer Society (#E-92B) and from the National Institutes of Health (#E-1940) and (SA-43-PH2440).

² Supported by National Cancer Institute Training Grant (CRT-5033).

³ Publication No. 113 from the Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts.

This article has been cited by other articles:

				M Bustin, J Reisch, L Einck, and J. Klippel Autoantibodies to nucleosomal proteins: antibodies to HMG-17 in autoimmune diseases Science, March 5, 1982; 215(4537): 1245 - 1247. [Abstract] [PDF]

				J. Panijel, C. Souleil, and P. Cayeux Immunochemical Characterization of Polyribonucleotides Science, May 6, 1966; 152(3723): 773 - 775. [Abstract] [PDF]