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The Immunochemistry and Genetics of Blood Group O

II. A Study of the Secretion of Blood Group A, B and O (H) Substances in the Saliva of Family Groups Using Precipitating Antibody Prepared in Chickens¹

From the Departments of Microbiology and Anatomy, Tulane University School of Medicine, New Orleans, Louisiana

Abstract

A precipitating antiserum, obtained by the immunization of chickens with purified blood group substance derived from the pseudomucinous ovarian cyst fluid of a woman of group O, was employed to examine the nature of the antigen present in the saliva of individuals of the various ABO groups.

Although data in the present study are sufficient only to suggest a genetic hypothesis, it would seem that a three-allele scheme for genes representing O-antigens explains (with one exception) the segregation observed within families. In addition, the three-allele hypothesis is compatible with the observation that the amount of precipitate in an offspring did not exceed that of one of the parents.

Footnotes

¹ Supported by grants from the National Institutes of Health, Institute of Allergy and Infectious Diseases, and the National Foundation.

² Present address, Division of Biologics Standards, National Institutes of Health, Bethesda 14, Md.