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Quantitative Micro-Complement Fixation and Its Use in the Study of Antigenic Structure by Specific Antigen-Antibody Inhibition¹

From the Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts²

Abstract

1. A quantitative micromethod for the estimation of C' fixation is described. The method is capable of measuring antigens in millimicrogram quantities.

2. A use of the micro-C' fixation method is specifically illustrated by the quantitative inhibition of pneumococcus polysaccharide immune systems by oligosaccharides.

Footnotes

¹ Supported in part by Grant E-1940 from the National Institutes of Health and Grant E-92B from the American Cancer Society.

² Publication No. 109 from the Graduate Department of Biochemistry.

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