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Immunological Paralysis and Adoptive Immunity¹

Departments of Bacteriology and Immunology, Pathology and Surgery, Harvard Medical Schooland Peter Bent Brigham Hospital, Boston, Massachusetts

Abstract

Utilizing the adoptive technique of Mitchison, it has been shown that spleen or lymph node cell suspensions of paralyzed mice do not protect normal mice from subsequent challenge with the homologous pneumococcus, suggesting that there are no antibody forming cells in the donated suspensions. Paralyzed mice can be protected by the transfer of spleen or lymph node cells from immunized mice. Immune mice, injected with a paralyzing dose of SSS, are no longer immune.

Footnotes

This work was supported in part by a grant from the Atomic Energy Commission and by Grant H-2791 from the United States Public Health Service.