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The Effect of Route of Inoculation upon Development of Antibody in Rabbits¹

Wilmer Ophthalmological Institute of the Johns Hopkins Hospital and University, Baltimore, Maryland

Abstract

The results of the experiments described indicate that comparable titers of specific circulating antibodies are induced following inoculation of identical quantities of soluble antigen either intracorneally or intravitreously. These titers, in turn, are comparable with those induced when the same quantity of antigen is incorporated in adjuvant and injected intramuscularly. These three methods of antibody induction have in common two basic mechanisms: a) slow diffusion of antigen from the site of inoculation and, b) the infiltration of the inoculation site with cells involved in the production of antibody. The use of avascular ocular routes in experimental immunization schedules in animals is suggested if antigen is scarce or if the use of an adjuvant is not desired.

Footnotes

This work was supported in part by a grant from the Knights Templar Eye Foundation, Inc.

² Supported in part by a fellowship from the Council for Research in Glaucoma and Allied Diseases, Alfred P. Sloan Foundation.

³ Fight For Sight Student Fellow financed by the Abraham Silver Memorial Fund of the National Council to Combat Blindness, Inc., New York City.

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