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Inhibition of the Effect of Cortisone on Antibody Formation by Heterologous Spleen Cells¹

From the State Bacteriological Laboratory, Stockholm, and the Rheumatology Department, Karolinska Institute, Stockholm, Sweden

Abstract

This investigation is a study of the effect of heterologous spleen cells on antibody formation in cortisone-treated rats. The test object has been the hemolysin response in rats immunized by one intraperitoneal injection of sheep erythrocytes and given cortisone by a schedule leading to depression of antibody formation.

A single intraperitoneal injection of mouse spleen cells on the day of antigen injection significantly increased antibody formation in cortisone-treated rats. Washing of cells before injection did not influence the outcome. This restoring effect on antibody production could not be demonstrated when the cells were given in disintegrated form.

Absorption studies gave no evidence for a production of hemolysin by the transferred mouse cells. Neither did the profiles of the antibody curves indicate production of heterologous antibody globulin. Mechanisms by which the mouse cells may restore the host's own antibody forming capacity are discussed.

Footnotes

¹ The results of this work were briefly reported. See Proceedings of a Symposium on the Mechanisms of Antibody Formation, Publishing House of the Czechoslovak Academy of Sciences, Prague, 1960.