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Antibody Response to Homografts

VII. The Role of Complement in Cytotoxicity of Serum from Homografted Rabbits¹

From the Department of Surgery, University of California Medical Center, Los Angeles, California

Abstract

The serum of rabbits which have been homografted with skin was shown to be toxic to the lymph node cells of the skin donor. Fresh serum was toxic, and the activity of the serum declined rapidly upon standing overnight, freezing or heating at 56°C for 30 min. The loss of activity could be restored to a large extent by addition of fresh normal rabbit serum or fresh serum from the lymphocyte donor rabbit. Guinea pig complement exerted some inherent toxicity. The possibility that the detection of such cytotoxins may suggest a re-evaluation of the cellular basis of homograft immunity is discussed.

Footnotes

This work was supported by grants-in-aid from the National Institute of Arthritis and Metabolic Diseases, United States Public Health Service (No. A-2375), and from the California Institute for Cancer Research.

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