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Localization Properties of Radioiodinated Fragments of Antirat Kidney Antibody¹

From the Department of Biochemistry Research, Roswell Park Memorial Institute, Buffalo, New York

Abstract

Rabbit antibodies against rat kidney were digested by papain and the fragments were trace labeled with radioiodine and studied with respect to their in vivo localizing and in vitro adsorption properties. -Globulin fragments from normal rabbit and rabbit anti-beef -globulin sera were used as controls. The kidney-localizing activity was found in fragments I and II of antirat kidney -globulin. The fixation of fragments in the kidney, however, was of short duration compared with that of the intact antibody. The adsorption of fragments with kidney sediment also indicated the presence of antibody activity in fragments I and II.

Footnotes

This investigation was supported in part by Grant H-2092 of the National Heart Institute, U.S.P.H.S.

This article has been cited by other articles:

				J. H. Baxter and P. A. Small Jr. Antibody to Rat Kidney: In vivo Effects of Univalent and Divalent Fragments Science, June 28, 1963; 140(3574): 1406 - 1407. [Abstract] [PDF]