HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Goh, K.-O. Articles by Diamond, H. D. Search for Related Content PubMed PubMed Citation Articles by Goh, K.-O. Articles by Diamond, H. D.

An Investigation into the Use of 6-Mercaptopurine to Induce Immunological Tolerance¹

From the Lymphoma Service, Departments of Medicine, Memorial and James Ewing Hospitals, the Lymphoma Section, Division of Clinical Chemotherapy, Sloan-Kettering Institute for Cancer Research, and the Department of Medicine, Cornell University Medical College, New York City, New York

Abstract

1. Experiments to repeat 6-mercaptopurine induced immunological tolerance are reported.

2. 6-Mercaptopurine definitely suppresses antibody formation in the primary response with a dose of 6 mg/kg a day for 14 days from the day of antigen injection in most of the animals studied.

3. With pure antigens, it was not possible to produce immunological tolerance in rabbits pretreated with 6-MP in the experimental procedure indicated above.

4. Three animals showed immunological unresponsiveness or poor response to the second dose of antigen and to the first dose of another antigen. These animals were considered to be poor producers of circulating antibody.

Footnotes

This work was supported by a grant from the Lloyd F. Craver Fund of the Memorial Sloan-Kettering Cancer Center, New York, New York.

² Present address: Department of Medicine, University of Rochester Medical Center, Rochester 20, New York.