HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gaines, S. Articles by Tigertt, W. D. Search for Related Content PubMed PubMed Citation Articles by Gaines, S. Articles by Tigertt, W. D.

Enhancement of the Mouse Virulence of a Non-Vi Variant of Salmonella Typhosa by Vi Antigen¹

From the Department of Microbiology, Division of Special Operations, Walter Reed Army Institute of Research, Washington, District of Columbia

Abstract

Vi antigen was shown to be a major factor in the virulence of S. typhosa for mice. Employing the intracerebral route of infection and V and W variants of the Ty2 strain, it was observed that the Vi-containing culture was approximately 40 times more lethal than the variant devoid of this antigen.

The lethality of the W form was markedly increased when it was administered simultaneously with isolated, purified Vi antigen, and this virulence enhancement was shown to be specific. Furthermore, it was demonstrated that isolated Vi antigen did not become incorporated in the bacterial cell during the infectious process, and that this substance need not be an integral part of the bacterial cell in order to contribute to virulence.

Enhancement of the virulence of the W cells appeared to be due, at least in part, to the ability of Vi antigen to enhance the rate of increase in numbers of the infecting inoculum in vivo.

Footnotes

¹ Presented in part before the American Association of Immunologists, April, 1958, Philadelphia, Pa.

This article has been cited by other articles:

				J. Santander, S.-Y. Wanda, C. A. Nickerson, and R. Curtiss III Role of RpoS in Fine-Tuning the Synthesis of Vi Capsular Polysaccharide in Salmonella enterica Serotype Typhi Infect. Immun., March 1, 2007; 75(3): 1382 - 1392. [Abstract] [Full Text] [PDF]