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The VI Antigens of the Enterobacteriaceae

V. SEROLOGIC DIFFERENCES OF VI ANTIGENS REVEALED BY DEACETYLATION¹

From the Department of Microbiology, Boston University School of Medicine and the Department of Biology, Simmons College, Boston, Massachusetts

Abstract

Vi antigens and deacetylated Vi antigens from P. ballerup, E. coli and S. typhosa, strain Ty2 were tested with antisera prepared against various Vi producing microorganisms by the agar diffusion precipitin test. Differences in type of reaction were noted between deacetylated antigen preparations reacted with antisera prepared with P. ballerup or S. paratyphi C bacilli and deacetylated Vi antigens reacted with antisera prepared with S. typhosa or E. coli organisms. It appeared that serologic differences exist in Vi antigens of the various bacilli used for preparation of antisera which become evident when these antisera are reacted with degraded Vi antigens. It has been shown that these differences are not differences in basic specificity of Vi antigen and its antibody.

Footnotes

¹ This investigation was carried out under the sponsorship of the Commission on Immunization of the Armed Forces Epidemiological Board and was supported by the Offices of the Surgeon General, Department of the Army.