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Agglutinin Response, a Function of Cell Number

From the Biology Division, Oak Ridge National Laboratory, ¹ Oak Ridge, Tennessee

Abstract

Our in vivo culture studies revealed that, independent of a) the strain of mice; b) the type of particulate antigen; c) the time of bleeding after cell transfer and antigen injection; and d) whether animals were undergoing a primary or secondary antibody response, a linear log₂ antibody titer log₂ nucleated cell relation was obtained with spleen and peritoneal exudate cells. Furthermore, the slopes of the resulting regression lines for the primary and secondary responses did not differ significantly, but the antibody-forming activity per given number of nucleated cells was significantly greater in the secondary antibody response than in the primary antibody response. The optimum dose of RBC for a maximum sensitization was 1 ml of 1%, and no difference between intravenous and intraperitoneal routes of RBC injection was noted.

Footnotes

¹ Operated for Union Carbide Corporation for the U. S. Atomic Energy Commission.

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