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The Persistent Production of Small Quantities of Infectious Newcastle Disease Virus in Grossly Unaltered L and U₁₂ Strain Cells¹

From the Departments of Pathology, Western Reserve University School of Medicine and Cleveland Metropolitan General Hospital, Cleveland, Ohio

Abstract

Inapparent infections of L and U₁₂ cell strains by Newcastle disease virus are described in which low concentrations of virus were persistently elaborated by the cells. Detectable amounts of infectious virus were found more frequently in L strain cultures and appeared to be associated with the cell fractions in slightly greater quantities. Even though they contained virus, the carrier cell lines were as susceptible as previously uninoculated stock cell cultures to the toxic effect of large virus inocula.

Footnotes

This work was supported by USPH Service Grant No. C-1735 and grants from the Cuyahoga Units of the American Cancer Society and the Alice Keith Mather Fund of the Cleveland Foundation. A portion of this work was done under the terms of a Damon Runyon Cancer Research Fellowship.

² Present address: Department of Pathology, Michael Reese Hospital, 29th St. and Ellis Ave., Chicago, Ill.

³ Present address: Department of Pathology, Duke University Medical Center, Durham, N. C.