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Studies of Lymphocytic Choriomeningitis in Mice¹

I. THE RELATIONSHIP BETWEEN AGE AT INOCULATION AND OUTCOME OF INFECTION

From the Division of Laboratories and Research, New York State Department of Health, Albany, New York

Abstract

The ability of LCM virus to cause disease has been studied in mice after inoculation at various time intervals following birth. Two different strains of virus and host were used and the results of the four combinations compared.

It was found that, in general, less disease and mortality occurred as the interval between birth and inoculation decreased, except when this interval was very short (2 hr) which caused high mortality. Some variations occurred with the different combinations of host and virus.

Mice inoculated during the first few days after birth frequently passed through a "runt" stage for several weeks, with severe retardation of growth and hair development. It was concluded that LCM disease is an immunologic conflict between the host and the viral antigen; this can end in any one of three ways: a) immunological tolerance or paralysis (persistent tolerated infection); b) death of the host; c) suppression of virus with immunity of the host.

Footnotes

¹ Aided by a grant from the National Foundation.

This article has been cited by other articles:

				M. Hanaoka, S. Suzuki, and J. Hotchin Thymus-Dependent Lymphocytes: Destruction by Lymphocytic Choriomeningitis Virus Science, March 14, 1969; 163(3872): 1216 - 1219. [Abstract] [PDF]