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Effect of Antiserum and Antibiotics on Persistent Infection of HeLa Cells with Meningopneumonitis Virus¹

From the Department of Bacteriology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina

Abstract

1. The effect of antiviral agents on a persistent infection of HeLa cells with meningopneumonitis virus has been studied. Antiserum does not appear to have a significant effect. Penicillin, even when treatment is prolonged for 3 months, causes a drop in titer but does not completely remove the virus. Chloramphenicol treatment for 21 days and tetracycline for 14 days are sufficient to remove all traces of virus.

2. Tetracycline appears to have an in vitro effect on the virus.

Footnotes

This investigation was supported by Research Grant E-868 from the National Institute of Allergy and Infectious Diseases, Public Health Service.