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Studies on Allegedly Non-Complement-Fixing Immune Systems

I. A Heat Labile Serum Factor Requirement for a Bovine Antibody Complement-Fixing System¹

From the East African Veterinary Research Organization, and Animal Disease and Parasite Research Division, Agricultural Research Service, U. S. Department of Agriculture, Muguga, Kenya

Abstract

The inability of bovine antibody, in contrast to rabbit antibody, to fix guinea pig C' with soluble antigen preparation derived from M. mycoides was shown to be due to a requirement for a heat labile serum factor. A satisfactory C'-fixing reaction could be obtained using unheated immune bovine serum or heated immune bovine serum to which normal bovine serum, or serum from other species, had been added. The heat labile factor appeared to be neither properdin nor the second, third or fourth components of C'. Similarities between C'-fixing enhancing material and C'1 were noted but no conclusion with respect to their identity is warranted at this time.

Footnotes

¹ This paper is published under the terms of a Memorandum of Understanding between the East African Veterinary Research Organization, Muguga, Kenya, and the U. S. Department of Agriculture, A.R.S., Animal Disease and Parasite Research Division. Permission of both parties to publish this information is gratefully acknowledged by the authors.

² Mr. Knight is with the East African Veterinary Research Organization, Muguga, Kenya.

³ Dr. Cowan is with the Plum Island Animal Disease Laboratory, Animal Disease and Parasite Research Division, Agricultural Research Service, U. S. Department of Agriculture.