HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kind, L. S. Articles by Roffler, S. K. Search for Related Content PubMed PubMed Citation Articles by Kind, L. S. Articles by Roffler, S. K.

Reduction of the Anaphylaxis Enhancing and Adjuvant Effects of Bordetella Pertussis by a Prior Injection of B. Pertussis

From the Department of Microbiology, University of California School of Medicine, San Francisco, California

Abstract

Mice inoculated with Bordetella pertussis and bovine serum albumin have an enhanced sensitivity to anaphylactic shock when subsequently challenged with BSA. The incidence of anaphylaxis as well as the amount of circulating antibodies to BSA are both significantly reduced in mice injected with pertussis vaccine 5 days prior to sensitizing injections of pertussis vaccine and BSA. A prior injection of B. pertussis also significantly reduces the incidence of anaphylaxis in mice sensitized with BSA in Freund's adjuvant.