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Biological Activity of Aggregated -Globulin

III. PRODUCTION OF ARTHUS-LIKE REACTIONS¹

From the Department of Serology, the National Institute of Health, Tokyo, Japan, and California Institute of Technology, Pasadena, California

Abstract

1. A single injection of aggregated human and rabbit -globulin, obtained by coupling with bis-diazotized benzidine, induced Arthus-like reactions in normal guinea pigs. The aggregated -globulin and soluble BSA-anti-BSA complexes were comparable on a weight basis with respect to their biologic activity.

2. The activity of aggregated -globulin was dependent on the animal species from which the -globulin was derived. Neither aggregated bovine nor chicken -globulin showed activity. Horse -globulin induced the skin reaction upon aggregation, although it was less active than the aggregated human and rabbit -globulins.

3. Aggregated human -globulin prepared by heating and by coupling with bis-diazotized benzidine induced erythema-wheal reactions in humans.

Footnotes

¹ A part of this study was carried out in the laboratory of Dr. Dan H. Campbell, California Institute of Technology and was supported by the National Institute of Allergy and Infectious Diseases.