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Restoration of Serum Bactericidal Activity and Prevention of its Loss in X-Irradiated Mice¹

From the Departments of Medicine and Microbiology, University of Chicago, Chicago, Illinois

Abstract

1. The loss of normal serum bactericidal activity of CF-1 mice for a strain of Escherichia coli which occurs 12 hr after total-body x-irradiation (600 r) was prevented if yeast autolysate, yeast ribonucleic acid, homogenates of normal mouse spleens or bacterial endotoxin were injected hr before or hr after exposure to x-rays. Injection 18 hr before irradiation was without effect.

2. Injection of any of these substances during the postirradiation period, when bactericidal activity was absent, resulted in the appearance of bactericidins 18 hr after treatment.

3. Spleens removed from donor mice 1 or more hours after exposure to 600 r failed to restore bactericidins in irradiated recipients.

Footnotes

¹ This work was supported under U. S. Atomic Energy Commission contract No. AT(11-1)-46, and the A. B. Kuppenheimer Fund of The University of Chicago.

² National Science Foundation Cooperative Graduate Fellow in the Department of Microbiology during the year 1959–1960.