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Naturally Occurring Isoantibodies of the S Blood Group System in Cattle¹

From the Department of Genetics, University of Wisconsin, Madison, Wisconsin, and the Serology Laboratory, School of Veterinary Medicine, University of California, Davis, California

Abstract

Several normal sera with naturally occurring antibodies reactive with cattle cells possessing the subtype factors U₁ and U₂ are described and two representative ones are more fully characterized by absorption analyses. It was shown that these sera detect a new specificity called U', possessed by U₂ and not by U₁ cells. The results indicate strongly that the antigenic specificity called U₂ is qualitatively different from U₁.

The new U' reagents are useful in distinguishing cells containing U₁ and U₂ from those containing U₁ only. The naturally occurring antibodies exhibit a marked prozone, which is a distinctive feature that may have contributed to the failure to detect this specificity before now.

A development of general interest is the illustration that differences in specificity between two reagents can not always be detected by their patterns of reactivity with even a large panel of known cells.

Footnotes

¹ Paper No. 808 from the Department of Genetics, University of Wisconsin, Madison, Wisconsin, and from the Serology Laboratory of the School of Veterinary Medicine, University of California at Davis, California. The work at the University of Wisconsin was supported in part by the Research Committee of the Graduate School, from funds supplied by the Wisconsin Alumni Research Foundation and by a research grant (E-1643) from the Department of Health, Education and Welfare of the National Institutes of Health, U. S. Public Health Service.