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Species-Specific Antigens from the Cell Walls of the Agents of Meningopneumonitis and Feline Pneumonitis^1,2,

From the Department of Microbiology, University of Chicago, Chicago, Illinois and the Connecticut State Department of Health, Hartford, Connecticut

Abstract

When cell walls were prepared from the agents of meningopneumonitis and feline pneumonitis by treatment first with deoxycholate and then with trypsin, the group-specific antigens were found in the deoxycholate extract whereas the species-specific antigens remained in the cell walls. Group-specific antigens were demonstrated by complement fixation, whereas the presence of species-specific antigens was shown by both complement fixation and absorption of infectivity-neutralizing antibody. The deoxycholate extracts contained periodate-sensitive and periodate-resistant group antigens. The specific complement-fixing antigens of the cell walls resembled previously described specific antigens in being resistant to periodate but differed from them in not being destroyed by heating at 100°C. Unlike intact particles, the cell walls were not toxic for mice upon intravenous injection. The possible application of these findings to practical serology of the psittacosis group was discussed.

Footnotes

¹ Presented in part before the 60th Annual Meeting of the Society of American Bacteriologists at Philadelphia, May 3, 1960.

² Supported chiefly by Research Grants E-2633 (to M. R. R.) and E-1594 (to J. W. M.) from the National Institute of Allergy and Infectious Diseases, Public Health Service, and in part by grants from the Dr. Wallace C. and Clara A. Abbott Memorial Fund of the University of Chicago and from the Abbott Laboratories, North Chicago, Illinois.

³ Department of Microbiology, University of Chicago, Chicago 37, Ill.

⁴ Mr. and Mrs. Frank G. Logan Fellow, 1959. Present address: U. S. Army Chemical Corps, Fort Detrick, Frederick, Md.

⁵ Connecticut State Department of Health, Hartford 1, Conn.