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Studies on the Mechanism of Action of Emulsified Vaccines^1,2,

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan

Abstract

A model system in mice has been developed and defined, in which the adjuvant effect of emulsified vaccines was tested.

Studies on the temporal relationship of enhanced antibody response to vaccination with adjuvant vaccine have shown that the initial peak level of antibody is dependent on repositing the virus in situ for about 16 days. Other data emphasizing the importance of the early events that take place after vaccination with adjuvant vaccine came from studies on the rate of breakdown of emulsified vaccines carried out by injection of P³² containing emulsions, by the removal of the site of inoculation and by irradiation designed to block further antibody production. These experiments have demonstrated that mineral oil emulsified vaccines tend to release a large and effective portion of their antigen soon after inoculation.

Footnotes

¹ A thesis based upon this study was submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Horace H. Rackham School of Graduate Studies of the University of Michigan.

² This investigation was conducted under the auspices of the Commission on Influenza, AFEB, and was supported by the Office of the Surgeon General, U. S. Army, Washington, D. C.

³ Present address: Chief, Immunology Division, Sixth U. S. Army Medical Laboratory, Fort Baker, California.