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The Effect of Zymosan on the Phagocytosis of Foreign Erythrocytes¹

New England Institute for Medical Research, Ridgefield, Connecticut

Abstract

1. The disappearance of sheep erythrocytes in the rat and in the rabbit has been shown to be a rapid exponential function attributable to phagocytosis.

2. Following this initial erythrophagocytosis hemoglobin is released back into the circulation, reflecting the catabolic function of the reticuloendothelial system.

3. Zymosan causes an increased rate of removal of erythrocytes but does not alter the disappearance rate of foreign albumin.

4. The relationship of phagocytosis to antibody production and the fact that enhanced antibody formation in Zymosan-treated animals cannot be attributed to more efficient phagocytosis are discussed.

Footnotes

¹ These studies were aided by a contract between the Office of Naval Research, Department of the Navy, and the New England Institute for Medical Research, NR 103–448, and by National Science Foundation Grant No. G-3531.

² These studies were done while the author was a Fellow of the National Foundation. Present address: National Heart Institute, Bethesda, Maryland.