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The Antibody Response to Smallpox Vaccination as Measured by a Tissue Culture Plaque Method¹

Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland

Abstract

The measurement of neutralizing antibody response to smallpox vaccination by various test systems has been unsatisfactory because small amounts of residual, uncombined virus can multiply and obscure the result. This can be avoided by use of a tissue culture plaque technique which immobilizes the spread of residual active virus. It has been found that a successful primary vaccination elicits a uniformly good response as measured by both neutralization and hemagglutination-inhibition. In contrast, revaccination provokes a greater elevation in the neutralizing titer and this rise appears to be related to the circulating antibody level at the time of revaccination.

Footnotes

¹ A portion of these data was presented at the annual meeting of the Society of American Bacteriologists, Chicago, 1958.

² Present address: Department of Biologics Research, Chas. Pfizer & Co., Terre Haute, Indiana.

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