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The Journal of Immunology, 1960, 85: 190-196.
Copyright © 1960 by The American Association of Immunologists, Inc.
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The Reaction Between Dextrans and the Properdin-Complement System

I. Inhibition by Excess Dextran1

Myron A. Leon and Arnold Ransby

From the Department of Surgical Research, St. Luke's Hospital, Cleveland, Ohio

Abstract

The reaction between dextran B1254-FrL and the properdin-complement system of both guinea pig and human serum has been studied kinetically as a function of temperature, serum concentration and dextran concentration. Optimal reaction rates are obtained over the range of 20–143 {gamma} of dextran/ml reaction mixture. Increasing the concentration of dextran markedly inhibits the formation of the dextran-properdin complex. Practical considerations are discussed in regard to the screening of dextrans for reactivity in the properdin-complement system.

Footnotes

This work was supported by The Prentiss Foundation and National Institutes of Health Grant No. E1172(C2).






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