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A Cytopathogenic Effect of Influenza Virus (PR-8 Strain) for Mouse Fibroblastic (L) Cells In Vitro¹

From the M. Herbert Eisenhart Tissue Culture Laboratory of the Department of Bacteriology, The University of Rochester School of Medicine and Dentistry, Rochester, New York

Abstract

A lytic action of influenza A virus (PR-8) for L cells in vitro has been demonstrated which occurs only with large amounts of infectious virus. This action of the virus involves attachment, penetration, and a limited form of viral replication which results in the production of relatively large amounts of viral hemagglutinin but very small quantities of infectious virus which manifests no increased ability to replicate in L cells. This lytic action shows a close relationship in its sensitivity to ultraviolet light to the infectious property of the virus.

Footnotes

Supported by a research grant from the National Cancer Institute. National Institutes of Health, U. S. Public Health Service, Bethesda, Maryland.