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Cx-Reactive Protein Response in Rabbits during Immunization with Foreign Proteins^1,2,

From the Department of Radiology, School of Medicine, University of California, Los Angeles, California

Abstract

Primary immunization of rabbits with intravenous bovine serum albumin or human -globulin resulted in a biphasic Cx-protein response. The secondary response was attributed to the formation of antigen-antibody complexes in the vascular system, since Cx-protein responses could be elicited by intravenous injection of soluble antigen-antibody complexes, and by formation of complexes in vivo by passive transfer of homologous antibody followed by antigen. A secondary Cx-protein response did not occur following primary intravenous immunization with tobacco mosaic virus, an antigen which disappeared from the blood stream well ahead of the appearance of antibody.

Footnotes

This investigation was supported by Grant C-3615 from the National Cancer Institute, U.S. Public Health Service.

² Presented in part at the American Society of Pharmacology and Experimental Therapeutics, Federation of American Societies for Experimental Biology, Atlantic City, April, 1959.

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