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Continuous Synthesis of Antibody after Primary Immunization with Protein Antigens¹

From the Department of Chemistry, Indiana University, Bloomington, Indiana

Abstract

It has been demonstrated that formation of antibodies to innocuous protein antigens such as bovine serum albumin, guinea pig serum protein, egg albumin and its azo derivatives continues unabated for at least several months after either single or multiple antigen injections. The antibodies present in the immune sera are of the non-precipitating type. They are detected by the agglutination of antigen-coated red blood cells. The implications of this finding for the understanding of the mechanism of antibody formation in general and the secondary antibody response in particular are discussed.

Footnotes

This work was supported by research grants from the U. S. Public Health Service (RG 1852) and the National Science Foundation (G5468), and by contracts of the Indiana University Foundation with the U. S. Atomic Energy Commission (At-11-1-209) and the Office of Naval Research (NR 108-035).

² Fellow of the Jane Coffin Childs Memorial Fund for Medical Research. Present address: Division of Immunochemistry and Allergy Research, Royal Victoria Hospital, McGill University Clinic, Montreal, P.Q., Canada. This investigation has been aided by a grant from the Jane Coffin Childs Memorial Fund for Medical Research.