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Transfer of Delayed Hypersensitivity to Coccidioidin in Man¹

From the Departments of Medicine and Surgery, New York University College of Medicine and the Third (NYU) Medical and Surgical Divisions of Bellevue Hospital, New York, and the U.S. Naval Medical Research Unit Number One, Naval Biological Laboratory, School of Public Health, University of California, Berkeley, California

Abstract

1. Generalized delayed sensitivity to coccidioidin can be transferred in human subjects with DNase-treated leukocyte extracts obtained from sensitive donors. This has been accomplished in 23 out of 27 consecutive attempts with leukocyte extracts obtained from moderately to markedly sensitive donors, and in 5 out of 8 consecutive attempts with leukocytes obtained from minimally to moderately sensitive donors.

2. Attempts to transfer coccidioidin sensitivity with leukocyte extracts obtained from a negative donor were unsuccessful in 8 out of 9 consecutive trials.

3. Sensitivity to coccidioidin after transfer may persist up to 15 months, in the absence of exposure to Coccidioides immitis or repeated skin testing.

4. The results of transfer of coccidioidin sensitivity by this means generally parallel those obtained in man following the transfer of bacterial hypersensitivity using extracts of specifically sensitive donor leukocytes.

Footnotes

This study was supported in part by a Training Grant E.T.S. 2E-5 from the National Institutes of Allergy and Infectious Diseases, National Institutes of Health, U. S. Public Health Service and in part by the U.S. Naval Medical Research Unit Number 1, Naval Biological Laboratory, University of California, School of Public Health, Berkeley, California. The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large.

² Conducted under the sponsorship of the Commission on Streptococcal Diseases, Armed Forces Epidemiological Board and supported in part by the Office of the Surgeon General, Department of the Army, Washington, District of Columbia, and in part by a grant from the National Institute of Allergy and Infectious Diseases, Public Health Service E-1254 C-2.

³ Commander, (MC), USN, Commanding Officer, U. S. Naval Medical Research Unit Number One, University of California, Berkeley, California.

⁴ Conducted under the Sponsorship of the Commission on Acute Respiratory Diseases, Armed Forces Epidemiological Board and Supported in part by the Office of the Surgeon General, Department of the Army, Washington, District of Columbia.

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				R. G. Slavin and J. E. Garvin Delayed Hypersensitivity in Man: Transfer by Lymphocyte Preparations of Peripheral Blood Science, July 3, 1964; 145(3627): 52 - 53. [Abstract] [PDF]