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Some Kinetic Aspects of the Combination of Antigen and Antibody in Vivo¹

From the Allergy Research Laboratory, Department of Medicine, Northwestern University Medical School, Chicago, Illinois

Abstract

1. Passively sensitized guinea pigs challenged intravenously with sublethal amounts of antigen are protected against subsequent lethal challenge.

2. Desensitization is not instantaneous but proceeds at a rate which is directly related to the quantity of antigen injected.

3. In the production of anaphylaxis, excess antigen may be required to develop an adequate rate of diffusion of antigen into the shock organ.

Footnotes

This investigation was supported in part by Research Grant No. E-1358 from the National Institute of Allergy and Infectious Diseases, U. S. Public Health Service, and by the Upjohn Company, Kalamazoo, Michigan. Presented in part before the American Association of Immunologists, April, 1959, at Atlantic City, New Jersey.