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Studies on Variation in Coxsackie A-9 Virus¹

From the Section of Epidemiology and Preventive Medicine, Yale University School of Medicine, New Haven, Connecticut

Abstract

After 6 to 14 serial passages of Coxsackie A-9 virus in x-irradiated patas cultures, a strain was obtained which a) multiplied in patas cultures, b) was reduced in virulence for new born mice, and c) produced only small plaques (5 mm at 7 days) on both rhesus and patas monolayers.

A single passage of the adapted virus either in mice or in rhesus cultures (both in fluid medium and under agar), shifted the virus population toward the original large plaque type and tissue culture host range.

Reversion to the large plaque type was observed after 4–8 hr growth (single growth cycle) when the adapted virus at limiting dilutions was transferred to rhesus cultures. However, if harvests were made after 24–48 hr a mixed plaque size population was obtained. This was attributed to a slower growth rate in the adapted virus.

Footnotes

¹ Aided by a grant from the National Foundation.