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Phosphate Metabolism of Spleen Cells in Antibody Formation¹

From the Connective Tissue Study Group of the Department of Medicine, Medical College of Virginia, Richmond, Virginia

Abstract

1. The phosphate metabolism of spleen cell preparations has been measured by the uptake of P³² phosphate into acid soluble, fat soluble, ribonucleic acid and desoxyribonucleic acid phosphate fractions.

2. Spleen cell preparations making antibody in vitro, after anamnestic in vivo stimulation with alum precipitated Ea, showed markedly raised uptake into all fractions, compared with nonantibody forming cells.

3. The significance of these findings is discussed.

Footnotes

This work was supported by U. S. Public Health Service Grant E 1305 (E2349).

² Present address University of Rochester School of Medicine and Dentistry, Rochester 20, New York.

³ Supported by a Fellowship from the Virginia Chapter of the Arthritis and Rheumatism Foundation.

⁴ Markle Scholar in Medical Sciences.