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Studies of a Complement-Fixing Antigen from Group A Streptococcal l Forms^1,2,

I. Preparation and Preliminary Tests in Rabbits and Man

From the Division of Immunology, Naval Medical Research Unit No. 4, U. S. Naval Training Center, Great Lakes, Illinois

Abstract

Extracts of L forms of a type 19 strain of group A streptococcus were found to react against certain animal and human sera in the Kolmer complement-fixation test. Sera from human subjects with presumably recent streptococcal experience were more often reactive than that from control groups. Antisera from rabbits immunized with group A and group C streptococci and with homologous group A L forms uniformly exhibited significant reactivity, whereas control rabbits and those immunized with other species and genera of Gram-positive cocci did not. Complement-fixing antigen was not extractable from the whole streptococcal cell by the same procedures, nor could the anti-L titer be reduced or removed from a human serum by adsorption with streptococci or cell wall preparations.

Footnotes

¹ From Research Project NM 52 06 04, the Bureau of Medicine and Surgery, U.S. Navy Department, Washington, D. C.

² Presented in part before the meeting of the Society of American Bacteriologists, St. Louis, Missouri, May 1959.