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Studies in Immunization

I. The Effect of Route of Injection of Bovine Serum Albumin in Freund Adjuvant on Production of Circulating Antibody and Delayed Hypersensitivity¹

From the Department of Bacteriology and Immunology, Harvard Medical School, and the Medical and Neurological Services, Massachusetts General Hospital, Boston, Massachusetts

Abstract

The effect of the route of immunization on the response of rabbits to BSA in Freund adjuvant has been studied. Intramuscular and subcutaneous injection gave the highest circulating antibody levels, toe pad and intraperitoneal injections were intermediate, and intradermal and intravenous injections were least effective. The toe pad and intradermal routes were most effective for production of delayed hypersensitivity; the intramuscular, subcutaneous and intraperitoneal routes were less effective, and the intravenous completely ineffective. An intravenous booster injection suppressed delayed hypersensitivity in all cases and caused significant increases in circulating antibody in animals inoculated by the intraperitoneal, intradermal, intravenous, and toe pad routes.

Footnotes

This study was supported by grants from the National Institutes of Health, U.S.P.H.S. (E-1289 and E-1257). It was presented in part before the Seventh International Congress for Microbiology, August 1958.

² National Neurological Research Foundation Scientist.

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