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Electrophoretic Studies on the Serum Protein Pattern of the Germfree Rat and Its Changes upon Exposure to a Conventional Bacterial Flora^1,2,

From the University of Notre Dame, Notre Dame, Indiana

Abstract

Germfree rats were taken out of the Reyniers germfree system and the electrophoretic pattern of the serum studied directly after removal and after exposure to a conventional environment and contact with conventional rats for various lengths of time. Compared to the values found in conventional rats, the germfree animals show lower -2, - and -globulin values, but higher albumin levels. After 1 week of exposure the exgermfree rats demonstrated an increase of the serum -2 fraction followed in the second week by an increase in the fraction. Only after more than 2 weeks of exposure the serum 7gg-globulin fraction was found to increase. As the globulin content increased, a concomitant decrease of the serum albumin fraction occurred causing the total serum protein content of germfree, "transition" and conventional animals to be approximately the same.

Footnotes

"This research was supported specifically by a grant from the Gustavus and Louise Pfeiffer Research Foundation; also generally by Office of Naval Research and the Army Surgeon General (Contract NONR-1623), by National Institutes of Health (Grant A-566) and by the University of Notre Dame."

² These data were presented in part at the IV International Congress of Biochemistry, Vienna, 1958.

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