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A Guinea Pig Potency Test for Adenovirus Vaccine

From the Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, District of Columbia

Abstract

An assay for potency of adenovirus vaccine in guinea pigs based on the antigen extinction principle is described. The potency test values in repeat titrations were reproducible within a maximal 7-fold range. Further need for control with a standard reference vaccine is indicated. Potency values for a number of vaccines of diverse origin are presented. These ranged in potency from 66-fold difference for type 4 to 1667-fold difference for type 7 component. The correlation of animal potency value with efficacy in field trials and the limitations of the test are discussed.

Footnotes

¹ Present address: Merck Institute for Therapeutic Research, West Point, Pa.