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The Agglutination of L Cells by Vaccinia Virus

I. The Agglutination and Agglutination-Inhibition Titrations for Virus and Antibody

From the United States Army Chemical Corps, Fort Detrick, Frederick, Maryland

Abstract

Each of the three strains of vaccinia virus investigated agglutinated L cells. The observation that the agglutination was induced by the virus and not by the soluble hemagglutinin permitted the development of methods for the titration of the virus and agglutination-inhibiting antibody. By means of the agglutination titer, virus infectivity may be accurately estimated in samples containing more than 10⁵ mouse LD₅₀/ml. The test for antibody is somewhat more sensitive and reproducible than the pock-neutralization test, and far more sensitive and accurate than the mouse IC neutralization test. The tests may be performed and read within 24 hr, and are convenient and economical to use.

Footnotes

¹ Present address: Chas. Pfizer and Company, Terre Haute, Indiana.

² Present address: Michigan State Department of Health, East Lansing, Michigan.