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Differences in Stability of Antigen-Antibody Complexes Formed with Poliovirus and Acute and Convalescent Phase Human Sera¹

From the Department of Pediatrics, New York University College of Medicine, New York, New York

Abstract

The relative stability of antibody-poliovirus complexes was studied, comparing acute and convalescent phase human sera. At pH 7.5, the rate of reactivation of virus upon dilution of serum-virus mixtures was found to be higher with acute phase sera than with convalescent phase antibody. At pH 4.0, the rate is increased, allowing in 1 hr at 37°C for up to 99% reactivation with acute and up to 23% with convalescent type sera.

Footnotes

¹ Aided by a grant from the Sister Elisabeth Kenny Foundation.

² Recipient of a Sister Elisabeth Kenny Scholarship.

³ Present address: Children's Hospital, 4614 Sunset Boulevard, Los Angeles 27, California.