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Kinetics of Human Complement¹

IV. Kinetics of the Inactivation of the C'3 Complex by Hydrazine

Department of Surgical Research, Saint Luke's Hospital, Cleveland 4, Ohio

Abstract

1. A serum factor involved in the terminal, cation-independent stage of immune hemolysis is inactivated by hydrazine.

2. The reaction kinetics favor a bimolecular mechanism for the inactivation.

3. The reaction exhibits no Ca⁺⁺ or Mg⁺⁺ requirements and the rate is independent of ionic strength.

4. The activation energy has been determined and the effect of pH investigated.

5. The evidence indicates that the hydrazine reacts in the form of uncharged, free base.

6. The inactivating properties of certain other reagents have been noted and discussed.

Footnotes

This work was supported by the Prentiss Foundation and by Public Health Service Grant E1686.