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Antigenicity of Polypeptides (Poly Alpha Amino Acids)¹

From the Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh 13, Pennsylvania

Abstract

The antigenicity in rabbits of various synthetic polypeptides has been studied. Employing both in vitro and in vivo tests for detecting antibody, it was shown that, of all the materials studied only the copolymer of glutamic acid and lysine (450–200B) was antigenic, and this was weakly so. The specificity of the antigen-antibody reaction and the future use of anticopolymer sera has been discussed.

Footnotes

¹ This is publication No. 189 of the Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh 13, Pennsylvania. This work supported by the Department of the Army, Office of the Surgeon General, Contract No. DA-49-007-MD-248 and Contract No. DA-49-007-MD-219 and by Grant No. CY3335 from the National Cancer Institute, U.S.P.H.S.

² Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh 13, Pennsylvania.

³ Weizmann Institute, Rehovoth, Israel.

⁴ Children's Cancer Research Foundation, Boston 15, Massachusetts.

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