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The Journal of Immunology, 1959, 83: 184-188.
Copyright © 1959 by The American Association of Immunologists, Inc.
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Relation of Secondary Antigen Injection to Time of Irradiation on Antibody Production in Mice

T. Makinodan, Betsy H. Friedberg, M. Guthrie Tolbert and N. Gengozian

From the Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennesse1

Abstract

1. The maximum depression period of the secondary antibody response takes place when antigen is injected 1 day before to 1 hr after x-radiation.
2. Recovery of the secondary immune mechanism of irradiated mice takes place within 2 weeks.
3. Above-normal mean total titers were observed when a second antigen injection is given 5 and 10 days after 710 r.
4. No significant decrease or increase in mean peak titer was observed regardless of the x-radiation-secondary antigen injection time relationship.

Footnotes

1 Operated by Union Carbide Corporation for the U. S. Atomic Energy Commission.






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