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The Journal of Immunology, 1959, 83: 116-126.
Copyright © 1959 by The American Association of Immunologists, Inc.
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Biologic Activity of Soluble Antigen-Antibody Complexes

IV. THE INHIBITION OF THE SKIN REACTIVITY OF SOLUBLE COMPLEXES AND THE PCA REACTION BY HETEROLOGOUS COMPLEXES1

Kimishige Ishizaka2 and Dan H. Campbell

From the Division of Chemistry and Chemical Engineering, The California Institute of Technology,3 Pasadena, California

Abstract

1. Both the skin reaction with BSA-anti-BSA complexes and sensitization with rabbit antibody in the PCA reaction are inhibited by normal rabbit {gamma}-globulin and human {gamma}-globulin. Neither horse {gamma}-globulin nor chicken {gamma}-globulin has any inhibitory effect in either type of reaction.
2. Heterologous skin reactive antigen-antibody complex blocks the sensitization of guinea pig skin with antibody in the PCA reaction.
3. Some inactive complexes of antigen-antibody systems; e.g., the Ag2Ab complex of the BSA system, the R-anti-R complex and the diphtheria toxoid-horse antitoxin complex, inhibit the skin reaction with active complexes and block the sensitization with heterologous antibody in the PCA reaction. Other inactive complexes such as the SII-rabbit anti-SII complex and human {gamma}-globulin-chicken anti-HGG complex do not.
4. The data suggest that the combination of the soluble complexes with the tissue constituent(s), to which the antibody combines upon sensitization, is one of the necessary processes of the skin reaction induced by antigen-antibody complexes.
5. A tentative hypothesis concerning the mechanism of the skin reaction is presented.

Footnotes

This work was supported by a grant from the National Institute of Allergy and Infectious Diseases.

2 Fulbright Fellow; permanent address—The National Institute of Health, Tokyo, Japan.

3 Contribution No. 2428.






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